Problems in Titration of Streptomycin

Streptomycin resistance in a streptomycin-producing microorganism.

Cell-free extracts of Streptomyces bikiniensis contain an adenosine 5'-triphosphate-dependent kinase which inactivates streptomycin (Sm) and dihydrostreptomycin by phosphorylation. The products have been identified as streptomycin 6-phosphate and dihydrostreptomycin 6-phosphate. Activity was not present in logarithmic-phase cells, which were susceptible to 25 mug of Sm per ml. In stationary-pha...

Streptomycin

ever, certain adjuvants, e.g. para-aminosalicylic acid, may delay the development of drug-resistance. Streptomycin is not absorbed from the alimentary tract and, therefore, it must always be given intramuscularly as well as directly, where possible, into the spaces which it is desired to render free from bacteria. The drug is excreted by the kidney. After intramuscular injection an adequate blo...

Streptomycin

THIS book is a practical guide wlhiclh deals with imiost of the cond(litionis which come wvithin the scope of plastic surgery as practised in the British Isles. The first six chapters arc devoted to basic principles such as the' use of free skin grafts, flaps and tube pedicles, transplantation of tissues othelthan skini and the treatment of wounds, burns, frostbite, scars and(i keloids. The nex...

Optimized preparation and evaluation of 99mTc-Streptomycin

Introduction: The endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics. Methods:Tc-99m labeled streptomycin was prepared using freshly milked 99mTcO4- and various concentrations of streptomycin, stannous chloride at various temperatures in high yield radio...

Streptomycin